4.0 Article

Antitumoural activity in Antarctic and sub-Antarctic benthic organisms

Journal

ANTARCTIC SCIENCE
Volume 22, Issue 5, Pages 494-507

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954102010000416

Keywords

Bouvet Island eastern Weddell Sea; invertebrates marine benthos pharmacology; South Shetland Islands

Funding

  1. ECOQUIM
  2. ACTIQUIM [REN2003 00545, REN2002 12006E/ANT, CGL2004 03356/ANT, CGL2007 65453/ANT]

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A prospecting search for antitumoural activity in polar benthic invertebrates was conducted on Antarctic and sub Antarctic benthos in three different areas Bouvet Island (sub Antarctic) eastern Weddell Sea (Antarctica) and the South Shetland Islands (Antarctica) A total of 770 benthic invertebrate samples (corresponding to at least 290 different species) from 12 different phyla were assayed to establish their pharmacological potential against three human tumour cell lines (colorectal adenocarcinoma lung carcinoma and breast adenocarcinoma) Bioassays resulted in 15 different species showing anticancer activity corresponding to five different phyla Tunicata (5) Porifera (4) Crudaria (3) Echmodermata (2) and Annelida (1) This appears to be the largest pharmacological study ever carried out in Antarctica and it shows very promising antitumoural activities in the Antarctic and sub Antarctic benthos

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