Journal
JOURNAL OF NEUROSCIENCE
Volume 25, Issue 44, Pages 10273-10281Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2386-05.2005
Keywords
acetylcholine; episodic buffer; sustained activity; computational modeling; working memory; persistent spiking
Categories
Funding
- PHS HHS [61492, 16454, 60013, 60450] Funding Source: Medline
Ask authors/readers for more resources
Acetylcholine may regulate working memory for novel stimuli by activating intrinsic mechanisms for sustained spiking in entorhinal cortical neurons, which have been demonstrated in slice preparations of the entorhinal cortex. Computational modeling demonstrates that loss of the cholinergic activation of intrinsic mechanisms for sustained activity could selectively impair working memory for novel stimuli, whereas working memory for familiar stimuli could be maintained because of previously modified synapses. Blockade of muscarinic cholinergic receptors and selective cholinergic lesions has been shown to impair encoding in delayed matching tasks. However, previous studies have not compared explicitly the role of cholinergic modulation in working memory for novel versus familiar stimuli. Here, we show that lesions of the cholinergic innervation of the entorhinal cortex selectively impair delayed nonmatch to sample performance for novel odors, whereas delayed nonmatch to sample for familiar odors is spared. This indicates an important role for cholinergic innervation of the entorhinal cortex in working memory for novel stimuli.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available