Electrochemical behavior of vardenafil on glassy carbon electrode:: Determination in tablets and human serum

The voltammetric behavior of vardenafil was studied on glassy carbon electrode using cyclic, differential pulse (DPV) and Osteryoung square-wave (OSW) voltammetric techniques. Vardenafil exhibited irreversible anodic waves over the pH range 1.00-12.00 in different supporting electrolytes. The current-concentration plot was rectilinear over the range from 4 x 10(-7) to 2 x 10(-5) M with correlation coefficient of 0.999. The wave was characterized as being irreversible and diffusion-controlled. The developed procedure was successfully applied to the determination of vardenafil in tablets and in spiked human serum. Furthermore, results obtained by the proposed method have been compared with high-performance liquid chromatographic method. (c) 2005 Elsevier B.V. All rights reserved.