Journal
MACROMOLECULAR BIOSCIENCE
Volume 5, Issue 11, Pages 1118-1124Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200500121
Keywords
L-histidine; micelle; L-phenylalanine; pK(a); stability
Ask authors/readers for more resources
Poly [(L-histidine)-CO-(L-phenylalanine)] -blockpoly(ethylene glycol) (HF-b-PEG) diblock copolymers were synthesized to be used for preparation of pH-sensitive polymeric micelles. First, HF block was synthesized by ring opening copolymerization of L-histidine and L-phenylalanine N-carboxy anhydride, and then the resulting copolymer was coupled with PEG. The pK(a) value of diblock copolymer can be controlled by adjusting the histidine/phenylalanine ratio in HF block. It is observed that the block copolymers form micelles in aqueous media and that the micelles are spherical in shape with a unimodal distribution. The micelle is formed at pH higher than pK(a) of block copolymer while it is not formed at lower pH. This is because the protonation of histidine residue in the HF block converts the hydrophobic core into hydrophilic one at lower pH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available