Journal
AIDS
Volume 19, Issue 16, Pages 1919-1922Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.aids.0000188425.79914.e4
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We examined the susceptibility of HIV-1 group M and 0 isolates to the fusion inhibitors T-20 and T-1249. Unexpectedly, HIV-1 0 isolates were as sensitive as group M viruses to inhibition by T-20 but were usually less susceptible to T-1249. Our data suggest that T-20 has broad antiretroviral activity and would be effective in individuals with HIV-1 0 infection. However, polymorphisms in gp41 might affect the sensitivity of HIV-1 0 to second-generation fusion inhibitors.
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