Inverse gas chromatographic determination of solubility parameters of excipients

The principle aim of this work was an application of inverse gas chromatography (IGC) for the estimation of solubility parameter for pharmaceutical excipients. The retention data of number of test solutes were used to calculate Flory-Huggins interaction parameter (chi(infinity)(1,2)) and than solubility parameter (delta(2)), corrected solubility parameter (delta(T)) and its components (delta(d), delta(P), delta(y),) by using different procedures. The influence of different values of test solutes solubility parameter (delta(1)) over calculated values was estimated. The solubility parameter values obtained for all excipients from the slope, from Guillet and co-workers' procedure are higher than that obtained from components according Voelkel and Janas procedure. It was found that solubility parameter's value of the test solutes influences, but not significantly, values of solubility parameter of excipients. (c) 2005 Elsevier B.V. All rights reserved.