Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 3, Issue 21, Pages 3851-3868Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b510458k
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It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3'-> 5'-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described.
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