Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 45, Pages 16315-16320Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0506190102
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Funding
- NCI NIH HHS [R56 CA016885, R01 CA016885] Funding Source: Medline
- NIAID NIH HHS [R01 AI054359, R01 AI062428, R56 AI062428, AI062428] Funding Source: Medline
- NIA NIH HHS [R21 AG19347, R21 AG019347] Funding Source: Medline
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The adaptive immune system relies on rare cognate lymphocytes to detect pathogen-derived antigens. Naive lymphocytes recirculate through secondary lymphoid organs in search of cognate antigen. Here, we show that the naive-lymphocyte recirculation pattern is controlled at the level of innate immune recognition, independent of antigen-specific stimulation. We demonstrate that inflarnmation-induced lymphocyte recruitment to the lymph node is mediated by the remodeling of the primary feed arteriole, and that its physiological role is to increase the efficiency of screening for rare antigen-specific lymphocytes. Our data reveal a mechanism of innate control of adaptive immunity: by increasing the pool of naive lymphocytes for detection of foreign antigens via regulation of vascular input to the local lymph node.
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