Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 280, Issue 45, Pages 38029-38034Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M509039200
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Funding
- NIA NIH HHS [R01AG19712, R01 AG019712, R01 AG025326-03, R01AG25326, R01 AG025326, R01 AG019712-05] Funding Source: Medline
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [0829438] Funding Source: National Science Foundation
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klotho is an aging suppressor gene and extends life span when overexpressed in mice. Klotho protein was recently demonstrated to function as a hormone that inhibits insulin/insulin-like growth factor-1 (IGF-1) signaling. Here we show that Klotho protein increases resistance to oxidative stress at the cellular and organismal level in mammals. Klotho protein activates the FoxO forkhead transcription factors that are negatively regulated by insulin/IGF-1 signaling, thereby inducing expression of manganese superoxide dismutase. This in turn facilitates removal of reactive oxygen species and confers oxidative stress resistance. Thus, Klotho-induced inhibition of insulin/IGF-1 signaling is associated with increased resistance to oxidative stress, which potentially contributes to the anti-aging properties of klotho.
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