Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 337, Issue 1, Pages 363-366Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2005.08.275
Keywords
alkali metal; cation binding; G-quartet; NMR; telomeric DNA
Categories
Ask authors/readers for more resources
We report the first direct solution NMR detection of the alkali metal cations (Na-23(+), K-39(+), and Rb-87(+)) residing inside G-quadruplex channel structures formed by guanosine 5 '-monophosphate and a DNA oligomer, d(TG(4)T). In solution, these channel alkali metal cations are tightly bound to the G-quadruplex structure and have been considered to be invisible to NMR spectroscopy for many years. Our finding that it is possible to directly observe these alkali metal cations by NMR spectroscopy provides a new tool for studying cation binding affinity and dynamics in G-quadruplex DNA. (c) 2005 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available