Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1094, Issue 1-2, Pages 187-191Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2005.07.082
Keywords
enantioseparation; single-isomer; positively charged beta-CD; capillary electrophoresis; mono-6-ammonium-6-deoxy-beta-cyclodextrin chloride
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A facile synthetic approach for mono-6-amino-6-deoxy-beta-cyclodextrin (beta-CD-NH2) was proposed. Its hydroxy chloride salt, mono-6-ammonium-6-deoxy-beta-cyclodextrin chloride (beta-CD-NH3Cl) was further prepared and used for the enantioseparation of various anionic and ampholytic analytes by capillary electrophoresis (CE). The effect of background electrolyte (BGE) pH and selector concentration on the enantioseparation was studied. Results showed that beta-CD-NH3Cl displayed powerful chiral resolution ability towards anionic analytes. In addition, baseline separation of a standard mixture consisting of eight acids was achieved within 35 min. (c) 2005 Elsevier B.V. All rights reserved.
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