Journal
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65
Volume 65, Issue -, Pages 225-257Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-arplant-050312-120229
Keywords
oxidosqualene cyclases; metabolic gene clusters; specialized metabolites; sterols; synthetic biology
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/J004561/1, BB/K005952/1, BBS/E/J/000C0644, BB/K003690/1, BB/I015345/1, BB/L014130/1, BBS/E/J/00000614, BBS/E/J/000CA372] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000CA533, BBS/E/J/000CA446, BB/L004372/1] Funding Source: researchfish
- BBSRC [BB/L014130/1, BBS/E/J/000CA446, BB/K003690/1, BB/K005952/1, BBS/E/J/000C0644, BBS/E/J/000CA533, BB/L004372/1, BBS/E/J/000CA372] Funding Source: UKRI
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The triterpenes are one of the most numerous and diverse groups of plant natural products. They are complex molecules that are, for the most part, beyond the reach of chemical synthesis. Simple triterpenes are components of surface waxes and specialized membranes and may potentially act as signaling molecules, whereas complex glycosylated triterpenes (saponins) provide protection against pathogens and pests. Simple and conjugated triterpenes have a wide range of applications in the food, health, and industrial biotechnology sectors. Here, we review recent developments in the field of triterpene biosynthesis, give an overview of the genes and enzymes that have been identified to date, and discuss strategies for discovering new triterpene biosynthetic pathways.
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