Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 70, Issue 23, Pages 9364-9370Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo051394l
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- PHS HHS [R-01 58108] Funding Source: Medline
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Aryl and alkenyl tosylates are easily prepared, inexpensive and, thus, attractive for transition-metal-catalyzed couplings, but their reactivity is low. We report examples of mild, palladium-catalyzed coupling of aryl, alkenyl, and alkyl Grignard reagents with aryl and alkenyl tosylates. The resulting biaryls, vinylarenes, and alkylarenes were isolated in good to excellent yield. These couplings were conducted with a nearly equimolar ratio of the two reactants, and many examples were conducted at room temperature.
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