Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 70, Issue 23, Pages 9377-9381Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo051453v
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Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido [2,3-b] pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.
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