Journal
TETRAHEDRON LETTERS
Volume 46, Issue 46, Pages 8027-8031Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.09.060
Keywords
boronates; petasis reaction; hexafluoropropanol
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Alcohols are solvents of choice to react boronates, aldehydes and either primary or secondary amines. Thus, while the reaction proceeds sluggishly, or not at all, in aprotic solvents, the desired aminoacids are in most cases obtained in high yields when conducted in methanol or hexafluoro-iso-propanol. In the case of secondary amines, microwave activation is shown to strongly accelerate the process without altering the yields. (c) 2005 Elsevier Ltd. All rights reserved.
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