Journal
ANNUAL REVIEW OF PLANT BIOLOGY
Volume 60, Issue -, Pages 335-355Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.arplant.043008.091955
Keywords
terpenes; P450; yeast; Escherichia coli; gene discovery
Categories
Funding
- National Science Foundation
- Office of Naval Research
- University of California Discovery Grant Program
- Maxygen
- Diversa
- Bill & Melinda Gates Foundation
- U.S. Department of Energy through the Joint BioEnergy Institute
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Isoprenoids are a large and highly diverse group of natural products with many functions in plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl diphosphate precursors through the action of terpene synthases and terpene-modifying enzymes such as cytochrome P450 monooxygenases. Many isoprenoids have important applications in areas such as human health and nutrition, and much effort has been directed toward their production in microbial hosts. However, many hurdles must be overcome in the elucidation and functional microbial expression of the genes responsible for biosynthesis of ail isoprenoid of interest. Here, we review investigations into isoprenoid function and gene discovery in plants as well as the latest advances in isoprenoid pathway engineering in both plant and microbial hosts.
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