Journal
ANNUAL REVIEW OF PHYSIOLOGY, VOL 76
Volume 76, Issue -, Pages 365-385Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021113-170400
Keywords
long-term potentiation; LTP; hippocampus; neuron; memory
Categories
Funding
- NIMH NIH HHS [R01 MH095090, R01 MH080047] Funding Source: Medline
- NINDS NIH HHS [R01 NS068410] Funding Source: Medline
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The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.
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