4.5 Article

Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 22, Pages 5012-5015

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.08.014

Keywords

CCR5; chemokine receptor modulator

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SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor. (c) 2005 Elsevier Ltd. All rights reserved.

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