Journal
ANNUAL REVIEW OF PHYSIOLOGY, VOL 74
Volume 74, Issue -, Pages 225-243Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-020911-153315
Keywords
glutamate corelease; neurotransmitter costorage; synaptic vesicle pools; vesicular neurotransmitter transporters
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH050712] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K01DA026504] Funding Source: NIH RePORTER
- NIDA NIH HHS [K01 DA026504, K01 DA026504-02] Funding Source: Medline
- NIMH NIH HHS [R01 MH050712] Funding Source: Medline
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Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H+ electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.
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