Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 72, Issue -, Pages 605-624Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021909-135815
Keywords
peripheral clocks; pacemaker neurons; locomotor activity; feeding; mating
Categories
Funding
- NIH [R01NS059042, R01NS052903]
- [F31NS062551]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS059042, R01NS052903, F31NS062551] Funding Source: NIH RePORTER
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Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in Drosophila, providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this simple model organism.
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