Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 72, Issue -, Pages 395-412Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021909-135725
Keywords
hypertension; blood pressure regulation; endogenous ouabain; endogenous cardiac glycosides; pregnancy; ACTH; volume expansion
Categories
Funding
- NIH [5 RO1 HL 28573, 5 RO1 HL 66062]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL066062, R01HL028573] Funding Source: NIH RePORTER
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The Na,K-ATPase is the membrane pump that generates the Na+ and K+ gradients across the plasma membrane that drives many physiological processes. This enzyme is highly sensitive to inhibition by cardiotonic steroids, most notably the digitalis/ouabain class of compounds, which have been used for centuries to treat congestive heart failure and arrhythmias. The amino acids that constitute the ouabain-binding site are highly conserved across the evolutionary spectrum. This could be fortuitous or could result from this site being conserved because it has an important biological function. New physiological approaches using genetically engineered mice are being used to define the biological significance of the receptor function of the Na,K-ATPase and its regulation by potential endogenous cardiotonic steroid-like compounds. These studies extend the reach of earlier studies involving the biochemical purification of endogenous regulatory ligands.
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