Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 71, Issue -, Pages 83-113Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.70.113006.100621
Keywords
cilia; cell proliferation; polycystic kidney disease; calcium signaling
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Funding
- NIDDK NIH HHS [DK074030, DK51050, R01 DK051050, R01 DK040703, R01 DK053357, R37 DK051050, DK40703, DK53357] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK051050, R37DK051050, R01DK040703, P50DK074030, R01DK053357] Funding Source: NIH RePORTER
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Polycystins are a family of eight-transmembrane proteins united by sequencc homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polycystin-1 and polycystin-2 in primary cilia and the cell cycle. Polycystins appear to play key roles during development, but a major question is their function in mature organs. Their roles in primary cilia, shear stress sensation, alteration of intracellular calcium, and planar cell polarity are examined. The third-hit hypothesis of polycystic kidney disease is discussed.
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