Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 71, Issue -, Pages 283-306Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.010908.163149
Keywords
cannabinoid; CB1; LTD; LTP; synaptic transmission; STDP; learning; drug addiction; Parkinson's disease
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Funding
- NIDA NIH HHS [R01 DA017392] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA017392] Funding Source: NIH RePORTER
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Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs are involved in neural functions ranging front feeding homeostasis to cognition. There is great interest in understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. Because behavioral adaptations are widely considered to rely on changes in synaptic strength, the prevalence of eCB-mediated long-term depress ion (eCB-LTD) at synapses throughout the brain merits close attention. The induction and expression of eCB-LTD, although remarkably similar at various synapses, are controlled by an array of regulatory influences that we are just beginning to uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory. In this article, we review the major molecular and cellular mechanisms underlying eCB-LTD, as well as the potential physiological relevance of this widespread form of synaptic plasticity.
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