Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 70, Issue -, Pages 273-299Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.70.113006.100618
Keywords
endoplasmic reticulum; mitochondria; secretory granules; endosomes; lysosomes
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Funding
- Medical Research Council [G9900432] Funding Source: Medline
- MRC [G9900432] Funding Source: UKRI
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Cytosolic Ca(2+) signals are crucial for the control of fluid and enzyme secretion from exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and complex Ca(2+) signaling mechanisms that exercise precise control of the secretory events occurring across the apical plasma membrane bordering the gland lumen. Ca(2+) stores in the endoplasmic reticulum, the secretory granules, the lysosomes, and the endosomes all play important roles in the generation of the local apical Ca(2+) spikes that switch on Cl(-) channels in the apical plasma membrane as well as exocytotic export of enzymes. The mitochondria are crucial not only for ATP generation but also for the physiologically important subcellular compartmentalization of the cytosolic Ca(2+) signals.
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