Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 70, Issue -, Pages 431-457Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.70.113006.100659
Keywords
MUC1; MUC4; MUC16; cancer; respiratory disease; signaling
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Funding
- NCI NIH HHS [P50CA116201, R01CA118944, R01CA64389] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA118944, R01CA064389, P50CA116201] Funding Source: NIH RePORTER
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Cell surface mucins are large transmembrane glycoproteins involved in diverse functions ranging from shielding the air-way epithelium against pathogenic infection to regulating cellular signaling and transcription. Although hampered by the relatively recent characterization of cell surface mucins and the difficulties inherent in working with molecules of their size, numerous studies have placed the tethered mucins in the thick of normal and diseased lung physiology. This review focuses on the three best-characterized cell surface mucins expressed in the respiratory tract: MUC1, MUC4, and MUC16.
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