Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 70, Issue -, Pages 239-255Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.70.113006.100506
Keywords
pancreatic polypeptide; peptide YY; glucagon-like peptide-1; oxyntomodulin; cholecystokinin; vagus nerve
Categories
Funding
- National Institute for Health Research [ACF-2006-21-010, NF-SI-0507-10337] Funding Source: researchfish
- MRC [G0701371] Funding Source: UKRI
- Medical Research Council [G0701371] Funding Source: Medline
Ask authors/readers for more resources
The increasing prevalence of obesity worldwide has imparted renewed impetus to the study of the mechanisms of appetite regulation. Digestion and nutrient absorption take place in the gastrointestinal (GI) tract, whereas food intake is controlled by neuronal circuits in the central nervous system. The need for gut-brain cross talk is therefore clear. It is now recognized that hormones released into the circulation from the GI tract in response to nutritional stimuli form a key component of this gut-brain axis. Peptides such as glucagon-like peptide-1, oxyntomodulin, pancreatic polypeptide, and peptide YY3-36 reduce food intake in both animal models and in humans. Physiologically, such peptides are thought to act as satiety signals and meal terminators. Here, we review the current state of the field of the effects of gut hormone action on appetite control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available