Journal
PSYCHIATRY RESEARCH
Volume 137, Issue 1-2, Pages 1-10Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2005.06.008
Keywords
TMS; resistant major depression; motor threshold; left dorsolateral prefrontal cortex
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This 5-week, randomized, double-blind, placebo-controlled trial investigated the efficacy and tolerability of high frequency repetitive transcranial magnetic stimulation (rTMS) directed to the left prefrontal cortex in drug-resistant depressed patients. Fifty-four patients were randomly assigned to receive 10 daily applications of either real or sham rTMS. Subjects assigned to receive active stimulation were divided into two further subgroups according to the intensity of stimulation: 80% vs. 100% of motor threshold (MT). At study completion, the response rates were 61.1 % (n = 11), 27.8% (n = 5) and 6.2% (n = 1) far the 100% NIT group, 80% MT group and sham group, respectively. A significant difference (Pearson chi(2) test) was found between the 100% MT and sham groups, while the 80% MT group did not differ significantly from the sham group. Between the two active groups, a marginally significant difference was observed. Analysis of variance with repeated measures on Hamilton Depression Rating Scale scores revealed a significantly different decrease over time of depressive symptomatology among the three treatment groups. Treatment response appeared to be unrelated to the demographic and clinical characteristics recorded, and on the whole the technique was well tolerated. The results of this double-blind trial showed that rTMS may be a useful and safe adjunctive treatment for drug-resistant depressed patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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