Journal
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 61
Volume 61, Issue -, Pages 305-322Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physchem.040808.090249
Keywords
secondary ion mass spectrometry; bioimaging; molecular depth profiling; three-dimensional molecular imaging; C(60); molecular dynamics
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Funding
- Direct For Mathematical & Physical Scien [0908226] Funding Source: National Science Foundation
- Division Of Chemistry [0910564] Funding Source: National Science Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002016] Funding Source: NIH RePORTER
- NIBIB NIH HHS [R01 EB002016-18, R01 EB002016-16, EB-002016-16, R01 EB002016] Funding Source: Medline
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This article reviews the new physics and new applications of secondary ion mass spectrometry using cluster ion probes. These probes, particularly C(60), exhibit enhanced molecular desorption with improved sensitivity owing to the unique nature of the energy-deposition process. In addition, these projectiles are capable of eroding molecular solids while retaining the molecular specificity of mass spectrometry. When the beams are microfocused to a spot on the sample, bioimaging experiments in two and three dimensions are feasible. We describe emerging theoretical models that allow the energy-deposition process to be understood on an atomic and molecular basis. Moreover, experiments on model systems are described that allow protocols for imaging on biological materials to be implemented. Finally, we present recent applications of imaging to biological tissue and single cells to illustrate the future directions of this methodology.
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