Journal
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Volume 49, Issue -, Pages 395-426Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.48.113006.094928
Keywords
store operated calcium entry (SOCE); capacitative calcium entry (CCE); calcium release activated calcium current (Icrac); G protein-coupled receptor (GPCR); phospholipase C (PLC)
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Funding
- Intramural Research Program of the VIII
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The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of sequence similarity. T RP channels are nonselective monovalent cation channels, most of which also allow passage of Ca2+. Many members of each of these families, but not all, are involved in sensory signal transduction. The C-type (for canonical or classical) subfamily, differs front the other TRP subfamilies in that it fulfills two different types of function: membrane depolarization, resembling sensory transduction TRPs, and mediation of sustained increases in intracellular Ca2+. The mechanism(s) by which the C-class of TRP channels-the TRPCs-are activated is poorly understood and their role in mediating intracellular Ca2+ increases is being questioned. Both of these questions-mechanism of activation and participation in Ca2+ entry-are the topics of this review.
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