Journal
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7
Volume 7, Issue -, Pages 61-98Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-011811-132445
Keywords
antigen presentation; antimicrobial; endocytosis; innate immunity; phagosome; receptor
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Engulfment and destruction of invading microorganisms by phagocytosis are critical components of the innate immune response. In addition, phagocytosis is also required for the clearance of apoptotic bodies, an essential aspect of tissue homeostasis and remodeling. Here, we summarize the current knowledge of the cellular and molecular basis of phagosome formation and maturation. We discuss the manner in which phagocytosis is subverted by certain pathogens and consider congenital disorders that affect phagocyte function.
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