Journal
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7
Volume 7, Issue -, Pages 123-144Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-011110-130227
Keywords
polyomavirus; primary cutaneous neuroendocrine cancer; large T antigen; small T antigen; digital transcriptome subtraction
Categories
Funding
- NCI NIH HHS [R01 CA136363, R01 CA136806, R33 CA120726, CA136363, CA120726] Funding Source: Medline
Ask authors/readers for more resources
Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein expression to survive. The integrated viral genomes have a tumor-specific pattern of tumor antigen gene mutation that incapacitates viral DNA replication. This human cancer virus provides a new model in which a common, mostly harmless member of the human viral flora can initiate cancer if it acquires a precise set of mutations in a host with specific susceptibility factors, such as age and immune suppression. Identification of this tumor virus has led to new opportunities for early diagnosis and targeted treatment of MCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available