Journal
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
Volume 5, Issue -, Pages 99-118Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-121808-102144
Keywords
aging; cancer; inflammation; proliferation; invasion
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Funding
- NIA NIH HHS [R37 AG009909, P01 AG017242, P01 AG041122] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P01AG017242, P01AG041122, R37AG009909] Funding Source: NIH RePORTER
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Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretor phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
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