Journal
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
Volume 5, Issue -, Pages 33-50Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-121808-102109
Keywords
glioblastoma; astrocytoma; genetic alterations; signaling pathway alterations
Categories
Funding
- National Institutes of Health-National Cancer Institute [CA109748, CA1 27620]
- NATIONAL CANCER INSTITUTE [R01CA127620, R01CA152883, R01CA109748] Funding Source: NIH RePORTER
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The ongoing characterization of the genetic and epigenetic alterations in the gliomas has already improved the classification of these heterogeneous tumors and enabled the development of rodent models for analysis of the molecular pathways underlying their proliferative and invasive behavior. Effective application of the targeted therapies that are now in development will depend on pathologists' ability to provide accurate information regarding the genetic alterations and the expression of key receptors and ligands in the tumors. Here we review the mechanisms that have been implicated in the pathogenesis of the gliomas and provide examples of the cooperative nature of the pathways involved, which may influence the initial therapeutic response and the potential for development of resistance.
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