Journal
BRAIN RESEARCH
Volume 1062, Issue 1-2, Pages 171-174Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2005.09.011
Keywords
neurotrauma; hormone; female; blood brain barrier; brain injury
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Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the present study, we demonstrate in both male and ovariectomized female rats that a single physiological dose of either hormone at 30 min after diffuse traumatic brain injury reduces both blood brain,barrier permeability and edema formation. We conclude that both hormones may contribute to reduce edema in females after brain injury. (c) 2005 Elsevier B.V. All rights reserved.
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