Journal
ANNUAL REVIEW OF NUTRITION, VOL 32
Volume 32, Issue -, Pages 287-309Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.nutr.012809.104655
Keywords
body weight; bone; caloric restriction; hormones; calcium; nutrients
Categories
Funding
- NATIONAL INSTITUTE ON AGING [R01AG012161] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG012161] Funding Source: Medline
Ask authors/readers for more resources
Excess body weight due to obesity has traditionally been considered to have a positive effect on bone; however, more recent findings suggest that bone quality is compromised. Both obesity and caloric restriction increase fracture risk and are regulated by endocrine factors and cytokines that have direct and indirect effects on bone and calcium absorption. Weight reduction will decrease bone mass and mineral density, but this varies by the individual's age, gender, and adiposity. Dietary modifications, exercise, and medications have been shown to attenuate the bone loss associated with weight reduction. Future obesity and weight loss trials would benefit from assessment of key hormones, adipokine and gut peptides that regulate calcium absorption, and bone mineral density and quality by using sensitive techniques in high-risk populations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available