Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 48, Issue 23, Pages 7166-7171Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm050565b
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To identify novel selective CB2 lead compounds, a comparative model of the CB2 receptor was constructed using the high-resolution bovine rhodopsin X-ray structure as a template. The CB2 model was utilized both in building the database queries and in filtering the hit compounds by a docking and scoring method. In G-protein activation assays, 1-isoquinolyl[3-(trifluoromethyl)phenyl]methanone (40, NRB 04079) was found to act as a selective agonist at the human CB2 receptor.
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