Journal
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34
Volume 34, Issue -, Pages 467-499Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-112210-112917
Keywords
olfactory sensory neurons; glomerular map formation; olfactory bulb; mitral and tufted cells; olfactory cortex
Categories
Funding
- Grants-in-Aid for Scientific Research [23240046] Funding Source: KAKEN
Ask authors/readers for more resources
Odor signals received by odorant receptors (ORs) expressed by olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) are represented as an odor map in the olfactory bulb (OB). In the mouse, there are similar to 1,000 different OR species, and each OSN expresses only one functional OR gene in a monoallelic manner. Furthermore, OSN axons expressing the same type of OR converge on a specific target site in the OB, forming a glomerular structure. Because each glomerulus represents a single OR species, and a single odorant can interact with multiple OR species, odor signals received in the OE are converted into a topographic map of multiple glomeruli activated with varying magnitudes. Here we review recent progress in the study of the mammalian olfactory system, focusing on the formation of the olfactory map and the transmission of topographical information in the OB to the olfactory cortex to elicit various behaviors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available