Journal
ANNUAL REVIEW OF NEUROSCIENCE, VOL 33
Volume 33, Issue -, Pages 71-88Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-060909-153144
Keywords
progranulin; TDP-43; neurodegeneration; etiological heterogeneity
Categories
Ask authors/readers for more resources
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition that predominantly affects behavior, social awareness, and language. It is characterized by extensive heterogeneity at the clinical, pathological, and genetic levels. Recognition of these levels of heterogeneity is important for proper disease management. The identification of progranulin and TDP-43 as key proteins in a significant proportion of FTLD patients has provided the impetus for a wealth of studies probing their role in neurodegeneration. This review highlights the most recent developments and future directions in this field and puts them in perspective of the novel insights into the neurodegenerative process, which have been gained from related disorders, e.g., the role of FUS in amyotrophic lateral sclerosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available