Journal
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68
Volume 68, Issue -, Pages 357-376Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-092412-155737
Keywords
sigma; RNA polymerase; transcription; gene expression
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Funding
- NIBIB NIH HHS [T32 EB009383] Funding Source: Medline
- NIGMS NIH HHS [T32GM008284, T32 GM008284] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB009383] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008284] Funding Source: NIH RePORTER
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Transcription initiation is the crucial focal point of gene expression in prokaryotes. The key players in this process, sigma factors (sigma s), associate with the catalytic core RNA polymerase to guide it through the essential steps of initiation: promoter recognition and opening, and synthesis of the first few nucleotides of the transcript. Here we recount the key advances in sigma biology, from their discovery 45 years ago to the most recent progress in understanding their structure and function at the atomic level. Recent data provide important structural insights into the mechanisms whereby ss initiate promoter opening. We discuss both the housekeeping sigma s, which govern transcription of the majority of cellular genes, and the alternative ss, which direct RNA polymerase to specialized operons in response to environmental and physiological cues. The review concludes with a genome-scale view of the extracytoplasmic function ss, themost abundant group of alternative sigma s.
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