Journal
ANNUAL REVIEW OF MICROBIOLOGY, VOL 66
Volume 66, Issue -, Pages 305-323Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-092611-150138
Keywords
small noncoding RNA; Schizosaccharomyces pombe; Neurospora
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Funding
- NIGMS NIH HHS [R01 GM062591, R01 GM068496] Funding Source: Medline
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RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The fission yeast Schizosaccharomyces pombe and the filamentous fungus Neurospora crassa have served as important model systems for RNAi research. Studies on these two organisms and other fungi have contributed significantly to our understanding of the mechanisms and functions of RNAi in eukaryotes. In addition, surprisingly diverse RNAi-mediated processes and small RNA biogenesis pathways have been discovered in fungi. In this review, we give an overview of different fungal RNAi pathways with a focus on their mechanisms and functions.
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