Journal
ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010
Volume 64, Issue -, Pages 43-60Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.112408.134247
Keywords
outer membrane protein; siderophore; active transport; signal transduction
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK036143] Funding Source: NIH RePORTER
Ask authors/readers for more resources
TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and transport ferric chelates, called siderophores, as well as vitamin B-12, nickel complexes, and carbohydrates The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane The siderophore substrates range in complexity from simple small molecules such as citrate to large proteins such as serum transferrin and hemoglobin Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-dependent regulators, sigma/anti-sigma factor systems, small RNAs, and even a riboswitch In recent years, many new structures of TBDTs have been solved in various states, resulting in a more complete understanding of siderophore selectivity and binding, signal transduction across the outer membrane, and interaction with the TonB-ExbB-ExbD complex However, the transport mechanism is still unclear In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available