Journal
ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010
Volume 64, Issue -, Pages 123-141Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.112408.134243
Keywords
miRNAs; herpesvirus; latency; viral miRNA targets; host-pathogen interactions
Categories
Funding
- NCI NIH HHS [T32 CA009111, T32-CA009111] Funding Source: Medline
- NIAID NIH HHS [R01 AI067968, R01-AI-067968] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [T32CA009111] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI067968] Funding Source: NIH RePORTER
Ask authors/readers for more resources
One of the most significant recent advances in biomedical research has been the discovery of the similar to 22-nt-long class of noncoding RNAs designated microRNAs (miRNAs) These regulatory RNAs provide a unique level of posttranscriptional gene regulation that modulates a range of fundamental cellular processes Several viruses, especially herpesviruses, also encode miRNAs, and over 200 viral miRNAs hive now been identified Current evidence indicates that viruses use these miRNAs to manipulate both cellular and viral gene expression Furthermore, viral infection can exert a profound impact on the cellular miRNA expression profile, and several RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential Here we discuss our current knowledge of viral miRNAs and virally influenced cellular miRNAs and their relationship to vim! infection
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available