Journal
ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010
Volume 64, Issue -, Pages 495-517Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.112408.134030
Keywords
melioidosis; glanders; bacterial pathogen; intracellular; virulence
Categories
Funding
- Wellcome Trust Funding Source: Medline
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Burkholderia pseudomallei and Burkholderia mallet are closely related gram-negative bacteria that can cause serious diseases in humans and animals This review summarizes the current and rapidly expanding knowledge on the specific virulence factors employed by these pathogens and their roles in the pathogenesis of melioidosis and glanders In particular, the contributions of recently identified virulence factors are described in the context of the intracellular lifestyle of these pathogens Throughout this review, unique and shared virulence features of B pseudomallei and B mallei are discussed
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