Journal
ANNUAL REVIEW OF MICROBIOLOGY
Volume 63, Issue -, Pages 335-362Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.091208.073353
Keywords
flagellum; cilium; motility; axoneme; trypanosome; dynein; cytokinesis
Categories
Funding
- USPHS National Research Service Award [GM07104]
- UCLA
- MARC [T34GM-08563-14]
- National Institutes of Health [R01AI52348]
- Arnold and Mabel Beckman Foundation
- Burroughs Wellcome Fund
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI052348] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T34GM008563, T32GM007104] Funding Source: NIH RePORTER
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African typanosomes are devastating human and animal pathogens. Typanosoma brucei rhodesiense and T. b. gambiense subspecies cause the fatal human disease known as African sleeping sickness. It is estimated that several hundred thousand new infections occur annually and the disease is fatal if untreated. T. brucei is transmitted by the tsetse fly and alternates between bloodstream-form and insect-form life cycle stages that are adapted to survive in the mammalian host and the insect vector, respectively The importance of the flagellum for parasite motility and attachment to the tsetse fly salivary gland epithelium has been appreciated for many years. Recent studies have revealed both conserved and novel features of T. brucei flagellum structure and composition, as well as surprising new functions that are outlined here. These discoveries are important from the standpoint of understanding trypanosome biology and identifying novel drug targets, as well as for advancing our understanding of fundamental aspects of eukaryotic flagellum structure and function.
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