Journal
ANNUAL REVIEW OF MICROBIOLOGY
Volume 63, Issue -, Pages 27-44Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.091208.073514
Keywords
repression; activation; autoregulation; protein-RNA interaction; RNA structure
Categories
Funding
- National Institutes of Health [GM52840, GM59969, GM66794]
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RNA binding proteins are capable of regulating translation initiation by a variety of mechanisms. Although the vast majority of these regulatory mechanisms involve translational repression, one example of translational activation has been characterized in detail. The RNA recognition targets of these regulators, proteins exhibit a wide range in structural complexity, with some proteins recognizing complex pseudoknot structures and others binding to simple RNA hairpins and/or short repeated single-stranded sequences. In some instances the bound protein directly competes with ribosome binding, and in other instances the bound protein promotes formation of in RNA structure that inhibits ribosome binding. Examples also exist in which the bound protein traps the ribosome in a complex that is incapable of initiating translation.
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