Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 305, Issue 1-2, Pages 180-185Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2005.09.010
Keywords
aerosol; ciprofloxacin; liposomes; powder; spray-freeze drying
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Spray-freeze drying was utilized to manufacture a liposomal powder formulation containing ciprofloxacin as a model active component. The powder forms liposomally encapsulated ciprofloxacin when wetted. Aerosol properties of this formulation were assessed using a new passive inhaler, in which the powder was entrained at a flow rate of 601/min. A mass median aerodynamic diameter (MMAD) of 2.8 mu m was achieved for this formulation. Using the experimental dispersion testing data, ciprofloxacin concentration in the airway surface liquid (ASL) was calculated using a Lagrangian deposition model. The reconstitution of the powder in various aqueous media gave drug encapsulation efficiencies as follows: 50% in water, 93.5% in isotonic saline, 80% in bovine mucin, 75% in porcine mucus and 73% in five-fold-diluted ex vivo human cystic fibrosis patient sputum. (c) 2005 Elsevier B.V. All rights reserved.
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