Journal
ANNUAL REVIEW OF MEDICINE, VOL 65
Volume 65, Issue -, Pages 157-170Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-092012-112344
Keywords
antimetabolites; nucleotide synthesis; isocitrate dehydrogenase; glutamine
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Therapeutic strategies designed to target cancer metabolism are an area of intense research. Antimetabolites, first used to treat patients in the early twentieth century, served as an early proof of concept for such therapies. We highlight strategies that attempt to improve on the antimetabolite approach as well as new metabolic drug targets. Some of these targets have the advantage of a strong genetic anchor to drive patient selection (isocitrate dehydrogenase 1/2, Enolase 2). Additional approaches described here derive from hypothesis-driven and systems biology efforts designed to exploit tumor cell metabolic dependencies (fatty acid oxidation, nicotinamide adenine dinucleotide synthesis, glutamine biology).
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