Journal
ANNUAL REVIEW OF MEDICINE, VOL 63
Volume 63, Issue -, Pages 317-328Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-043010-144749
Keywords
ER stress; unfolded protein response (UPR); neurodegenerative disease; liver disease; atherosclerosis; diabetes; cancer
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Funding
- NHLBI NIH HHS [R01 HL075662-09, P01 HL087123, P01 HL087123-05, R01 HL075662] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL087123, R01HL075662] Funding Source: NIH RePORTER
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Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling network that coordinates adaptive and apoptotic responses. There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress.
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