Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2005, Issue 23, Pages 4929-4949Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200500489
Keywords
dihydrofurans; heterocycles; natural products; synthesis; Heck reaction
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Many natural products and biologically active compounds contain the dihydrofuran subunit. Molecules incorporating either 2-substituted, 2,2-disubstituted 2,3- or 2,5-dihydrofurans are widespread in the literature and represent key molecular building blocks. The preparation of substituted dihydrofurans remains a current challenge in organic synthesis and this microreview details the various routes employed for their synthesis in the literature to the end of 2004. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
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