Journal
ANNUAL REVIEW OF MEDICINE
Volume 61, Issue -, Pages 1-15Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-011209-132719
Keywords
personalized medicine; genetic drug response; genetic drug toxicity
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Funding
- Essex Woodlands
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Humans have considerable genetic variation, as shown by their DNA sequence differences. Drug responsiveness and toxicity are affected by this variability. Genetic variation affects prodrug activation, drug targets, downstream activation pathways, drug elimination, and toxicity activation. Molecular diagnostic methods have discovered the genetic basis of several of these outlier drug responses. By predicting a patient's response, such diagnostics can improve both the safety and efficacy of drugs. The article illustrates the matching of molecular diagnosis to drug therapy for improved patient outcomes.
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